| First Author | Capparelli R | Year | 2004 |
| Journal | Mamm Genome | Volume | 15 |
| Issue | 8 | Pages | 579-84 |
| PubMed ID | 15457337 | Mgi Jnum | J:93064 |
| Mgi Id | MGI:3055679 | Doi | 10.1007/s00335-004-2351-y |
| Citation | Capparelli R, et al. (2004) Monoallelic expression of mouse Cd4 gene. Mamm Genome 15(8):579-84 |
| abstractText | A 7-bp deletion in the Cd4 gene, present in the strain MOLF/Ei of Mus musculus molossinus and absent in laboratory mouse strains ( Mus musculus musculus), provided the means to distinguish the parental origin of the Cd4 alleles expressed in single cells of F1 (AKR x MOLF/Ei) and F1 (Balb/C x MOLF/Ei) hybrids. Single-cell RT-PCR showed that the individual CD4+ lymphocyte expresses either the maternal or the paternal Cd4 allele, never both. In situ hybridization proved that Cd4 alleles replicate asynchronously, as expected in the case of genes expressed monoallelically. |
