| Primary Identifier | MGI:1345146 | Organism | mouse, laboratory |
| Chromosome | 8 | NCBI Gene Number | 24013 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable rhodopsin kinase activity. Acts upstream of or within several processes, including negative regulation of neuron apoptotic process; photoreceptor cell morphogenesis; and post-embryonic retina morphogenesis in camera-type eye. Located in photoreceptor outer segment. Is expressed in eye and retina outer nuclear layer. Used to study Oguchi disease-2. Human ortholog(s) of this gene implicated in Oguchi disease-2 and night blindness. Orthologous to human GRK1 (G protein-coupled receptor kinase 1). PHENOTYPE: Analysis of homozygous null mice revealed abnormal photoresponses and light-induced apoptosis in rods. Mutant mice may serve as models of Oguchi disease and retinal degeneration. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
