| First Author | Merlini M | Year | 2021 |
| Journal | Nat Neurosci | Volume | 24 |
| Issue | 1 | Pages | 19-23 |
| PubMed ID | 33318667 | Mgi Jnum | J:304867 |
| Mgi Id | MGI:6513709 | Doi | 10.1038/s41593-020-00756-7 |
| Citation | Merlini M, et al. (2021) Microglial Gi-dependent dynamics regulate brain network hyperexcitability. Nat Neurosci 24(1):19-23 |
| abstractText | Microglial surveillance is a key feature of brain physiology and disease. Here, we found that Gi-dependent microglial dynamics prevent neuronal network hyperexcitability. By generating Mg(PTX) mice to genetically inhibit Gi in microglia, we show that sustained reduction of microglia brain surveillance and directed process motility induced spontaneous seizures and increased hypersynchrony after physiologically evoked neuronal activity in awake adult mice. Thus, Gi-dependent microglia dynamics may prevent hyperexcitability in neurological diseases. |
