| Primary Identifier | IPR010750 | Type | Domain |
| Short Name | SGF29_tudor-like_dom |
| description | SAGA-associated factor 29 (SGF29) is involved in transcriptional regulation as a chromatin reader component of some histone acetyltransferase (HAT) SAGA-type complexes like the TFTC-HAT, ATAC or STAGA complexes [, , , , ]. SGF29 specifically recognises and binds methylated 'Lys-4' of histone H3 (H3K4me), with a preference for the trimethylated form (H3K4me3). It also may be involved in MYC-mediated oncogenic transformation [].This entry represents a the two tandem tudor-like domains found at the C-terminal of yeast and human SAGA-associated factor 29 proteins and the plant homologues. Each of them has a negatively-charged pocket capable of binding H3A1 and an aromatic cage for the recognition of H3K4me2/3 residues [, ]. |
