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Publication : Complement-related serine proteases in tunicates and vertebrates.

First Author  Matsushita M Year  1998
Journal  Curr Opin Immunol Volume  10
Issue  1 Pages  29-35
PubMed ID  9523107 Mgi Jnum  J:46428
Mgi Id  MGI:1197845 Doi  10.1016/s0952-7915(98)80027-7
Citation  Matsushita M, et al. (1998) Complement-related serine proteases in tunicates and vertebrates. Curr Opin Immunol 10(1):29-35
abstractText  Serum mannose-binding lectin binds to pathogens in association with a serine protease termed MASP, and in this form, plays a crucial role in innate immunity by activating complement in a manner similar to activation via the classical pathway. MASP, C1r and C1s belong to the same family of serine proteases. In addition to its presence in advanced species, MASP also exists in primitive life forms such as tunicates and may be an evolutionary prototype of this family.
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