| First Author | Okabe Y | Year | 2014 |
| Journal | Cell | Volume | 157 |
| Issue | 4 | Pages | 832-44 |
| PubMed ID | 24792964 | Mgi Jnum | J:214405 |
| Mgi Id | MGI:5602922 | Doi | 10.1016/j.cell.2014.04.016 |
| Citation | Okabe Y, et al. (2014) Tissue-specific signals control reversible program of localization and functional polarization of macrophages. Cell 157(4):832-44 |
| abstractText | Tissue-resident macrophages are highly heterogeneous in terms of their functions and phenotypes as a consequence of adaptation to different tissue environments. Local tissue-derived signals are thought to control functional polarization of resident macrophages; however, the identity of these signals remains largely unknown. It is also unknown whether functional heterogeneity is a result of irreversible lineage-specific differentiation or a consequence of continuous but reversible induction of diverse functional programs. Here, we identified retinoic acid as a signal that induces tissue-specific localization and functional polarization of peritoneal macrophages through the reversible induction of transcription factor GATA6. We further found that GATA6 in macrophages regulates gut IgA production through peritoneal B-1 cells. These results provide insight into the regulation of tissue-resident macrophage functional specialization by tissue-derived signals. |
