| First Author | Sato S | Year | 1990 |
| Journal | Toxicol Lett | Volume | 52 |
| Issue | 2 | Pages | 215-20 |
| PubMed ID | 2378005 | Mgi Jnum | J:27964 |
| Mgi Id | MGI:75598 | Doi | 10.1016/0378-4274(90)90156-g |
| Citation | Sato S, et al. (1990) A comparison of micronucleus induction in 3 mouse strains with representative clastogens. Toxicol Lett 52(2):215-20 |
| abstractText | The frequency of micronucleated polychromatic erythrocytes (MNPCEs) was compared in BALB/c, C57BL/6 and DBA/2 mice after the intraperitoneal injection (i.p.) of methyl methanesulfonate (MMS), potassium chromate (K2CrO4), colchicine (COL), cycloheximide (CYH), 4-nitroquinoline-1-oxide (4-NQO) and 5-fluorouracil (5-FU). In BALB/c mice, the frequency of MNPCEs was significantly increased by all the chemicals tested, as compared to the vehicle control. In both C57BL/6 and DBA/2 mice, MMS, K2CrO4, COL and 4-NQO significantly increased MNPCEs, but CYH and 5-FU only slightly increased the MNPCEs in C57BL/6 and had no effect on DBA/2 mice. These results suggest that BALB/c mice are more sensitive to the induction of MNPCEs with a wider spectrum of chemicals than C57BL/6 or DBA/2 mice. |
