| Primary Identifier | MGI:1346877 | Organism | mouse, laboratory |
| Chromosome | 4 | NCBI Gene Number | 26409 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables MAP kinase kinase activity; MAP kinase kinase kinase kinase activity; and receptor tyrosine kinase binding activity. Involved in several processes, including anoikis; negative regulation of necroptotic process; and positive regulation of canonical NF-kappaB signal transduction. Acts upstream of or within several processes, including intracellular signaling cassette; regulation of signal transduction; and tube morphogenesis. Located in postsynaptic density. Is expressed in several structures, including brain; gut; male reproductive gland or organ; metanephros; and respiratory system. Used to study Wolff-Parkinson-White syndrome. Human ortholog(s) of this gene implicated in frontometaphyseal dysplasia; frontometaphyseal dysplasia 2; and prostate cancer. Orthologous to human MAP3K7 (mitogen-activated protein kinase kinase kinase 7). PHENOTYPE: Homozygous null mice display embryonic lethality during organogenesis and may have impaired vascular remodeling, edema, or an open, wavy neural tube. Conditional immune-cell-specific homozygous knockout leads to enlarged spleen and lymph nodes and affects immune cell cytokine production, development and activation. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
