| Primary Identifier | IPR030843 | Type | Family |
| Short Name | PAN2 |
| description | Pan2 is a catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of the two eukaryotic poly(A) nuclease complexes (Ccr4-Caf1 and Pan2-Pan3) involved in mRNA decay [, ]. Pan2 is involved in the initial stage of deadenylation of mRNA, which is required for poly(A) tail shortening []. Regulation of mRNA decay rates in eukaryotic cells affects gene expression []. The Pan2-Pan3 complex shortens cytoplasmic mRNA 3' polyA tails to regulate mRNA stability []. In the complex Pan2 provides the catalytic activity, whereas Pan3 mediates Pan2 recruitment tomRNA targets []. |
