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Allele : Nrg1<tm1Fej> neuregulin 1; targeted mutation 1, Frank E Jones
Primary Identifier  MGI:2448075 Allele Type  Targeted
Attribute String  Conditional ready, No functional change Gene  Nrg1
Transmission  Germline Strain of Origin  129P2/OlaHsd
Is Recombinase  false Is Wild Type  false
molecularNote  The endogenous locus was modified to contain a stop codon in exon 7 and single loxP sites flanking exons 7, 8, and 9. The mutation was designed to specifically target the alpha isoform, which contains exon 7. RT-PCR analysis showed reduced levels of mRNA, putatively due to nonsense mediated decay.
  • mutations:
  • Insertion
  • synonyms:
  • HRGalpha-null,
  • HRGalpha-null
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1 Feature

Trail: Allele

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

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Trail: Allele




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