| First Author | Decrouy A | Year | 1993 |
| Journal | Experientia | Volume | 49 |
| Issue | 10 | Pages | 843-9 |
| PubMed ID | 8224098 | Mgi Jnum | J:15722 |
| Mgi Id | MGI:63837 | Doi | 10.1007/BF01952595 |
| Citation | Decrouy A, et al. (1993) Decreased rates of Ca(2+)-dependent heat production in slow- and fast-twitch muscles from the dystrophic (mdx) mouse. Experientia 49(10):843-9 |
| abstractText | Using a newly developed microcalorimetric approach to assess the rate of energy expenditure for intracellular [Ca2+] homeostasis in isolated muscles at rest, we found this was lower in mdx than in control mouse muscles, by 62% and 29% in soleus and extensor digitorum longus, respectively. Differences in total and Ca(2+)-dependent rates of specific heat production between mdx and control were enhanced during sustained, KCl-induced stimulation of energy dissipation. These results suggest that the low sarcoplasmic energy status of dystrophic muscles is not due to any excessive energy expenditure for intracellular [Ca2+] homeostasis. |
