| First Author | Willott JF | Year | 1990 |
| Journal | J Comp Neurol | Volume | 300 |
| Issue | 1 | Pages | 61-81 |
| PubMed ID | 2229488 | Mgi Jnum | J:27041 |
| Mgi Id | MGI:74459 | Doi | 10.1002/cne.903000106 |
| Citation | Willott JF, et al. (1990) Morphology of the octopus cell area of the cochlear nucleus in young and aging C57BL/6J and CBA/J mice. J Comp Neurol 300(1):61-81 |
| abstractText | The influence of aging and age-related cochlear impairment on the ventral cochlear nucleus was evaluated by measuring morphological properties of the octopus cell area (OCA) in five age groups of inbred C57BL/6J and CBA/J mice (young adult to very old). The former strain demonstrates progressive cochlear sensorineural pathology and hearing loss during middle age; the latter has only modest sensorineural pathology late in life. Histological sections of the OCA were evaluated with serial sections and several strains for neurons, glia, and fibers, and Golgi impregnations were also used. Aging was associated with a decrease in volume of the OCA, a loss of neurons, slight decrease in neuron size, increased packing density of glial cells, and changes in dendrites ranging from minor to total loss of primary branches. The greatest changes occurred in extreme old age, beyond the median lifespan. Age-related changes were not exacerbated by sensorineural pathology in aging C57BL/6J mice. Individual octopus cells varied greatly in the extent of age-related abnormality. |
