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Publication : Correlation of GDF5 and connexin 43 mRNA expression during embryonic development.

First Author  Coleman CM Year  2003
Journal  Anat Rec A Discov Mol Cell Evol Biol Volume  275
Issue  2 Pages  1117-21
PubMed ID  14613311 Mgi Jnum  J:87281
Mgi Id  MGI:2684002 Doi  10.1002/ar.a.10125
Citation  Coleman CM, et al. (2003) Correlation of GDF5 and connexin 43 mRNA expression during embryonic development. Anat Rec A Discov Mol Cell Evol Biol 275(2):1117-21
abstractText  Growth/differentiation factor 5 (GDF5) regulates connexin expression and enhances embryonic chondrogenesis in a gap junction-dependent manner, suggesting that GDF5 action on developmental skeletogenesis is coordinated with gap junction activities. The results shown here demonstrate concordance between the mRNA expression profiles of GDF5 and the gap junction gene, Cx43, in the mouse embryonic limb, spine, and heart, consistent with coordinated functions for these gene products during developmental organogenesis.
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