| First Author | Carl JW Jr | Year | 2008 |
| Journal | J Immunol | Volume | 181 |
| Issue | 1 | Pages | 320-8 |
| PubMed ID | 18566397 | Mgi Jnum | J:137407 |
| Mgi Id | MGI:3799437 | Doi | 10.4049/jimmunol.181.1.320 |
| Citation | Carl JW Jr, et al. (2008) Autoreactive T cells escape clonal deletion in the thymus by a CD24-dependent pathway. J Immunol 181(1):320-8 |
| abstractText | Despite negative selection in the thymus, significant numbers of autoreactive T cells still escape to the periphery and cause autoimmune diseases when immune regulation goes awry. It is largely unknown how these T cells escape clonal deletion. In this study, we report that CD24 deficiency caused deletion of autoreactive T cells that normally escape negative selection. Restoration of CD24 expression on T cells alone did not prevent autoreactive T cells from deletion; bone marrow chimera experiments suggest that CD24 on radio-resistant stromal cells is necessary for preventing deletion of autoreactive T cells. CD24 deficiency abrogated the development of experimental autoimmune encephalomyelitis in transgenic mice with a TCR specific for a pathogenic autoantigen. The role of CD24 in negative selection provides a novel explanation for its control of genetic susceptibility to autoimmune diseases in mice and humans. |
