Primary Identifier | IPR038487 | Type | Homologous_superfamily |
Short Name | Mre11_capping_dom |
description | The Mre11 complex is a multi-subunit nuclease that is composed of Mre11, Rad50 and Nbs1/Xrs2, and is involved in checkpoint signalling and DNA replication []. Mre11 has an intrinsic DNA-binding activity that is stimulated by Rad50 on its own or in combination with Nbs1 [].Mre11 dimerizes via phosphodiesterase domains flanked by a alpha/beta capping domain, process which creates a U-shaped particle with a broad DNA/Rad50 binding cleft []. This superfamily represents the Mre11 capping domain. |