| First Author | Ryoo S | Year | 2008 |
| Journal | Circ Res | Volume | 102 |
| Issue | 8 | Pages | 923-32 |
| PubMed ID | 18309100 | Mgi Jnum | J:149034 |
| Mgi Id | MGI:3847403 | Doi | 10.1161/CIRCRESAHA.107.169573 |
| Citation | Ryoo S, et al. (2008) Endothelial arginase II: a novel target for the treatment of atherosclerosis. Circ Res 102(8):923-32 |
| abstractText | Oxidized low-density lipoproteins increase arginase activity and reciprocally decrease endothelial NO in human aortic endothelial cells. Here, we demonstrate that vascular endothelial arginase activity is increased in atherogenic-prone apolipoprotein E-null (ApoE(-/-)) and wild-type mice fed a high cholesterol diet. In ApoE(-/-) mice, selective arginase II inhibition or deletion of the arginase II gene (Arg II(-/-) mice) prevents high-cholesterol diet-dependent decreases in vascular NO production, decreases endothelial reactive oxygen species production, restores endothelial function, and prevents oxidized low-density lipoprotein-dependent increases in vascular stiffness. Furthermore, arginase inhibition significantly decreases plaque burden. These data indicate that arginase II plays a critical role in the pathophysiology of cholesterol-mediated endothelial dysfunction and represents a novel target for therapy in atherosclerosis. |
