| First Author | Cattanach BM | Year | 1993 |
| Journal | Mouse Genome | Volume | 91 |
| Issue | 1 | Pages | 116 |
| Mgi Jnum | J:4296 | Mgi Id | MGI:52792 |
| Citation | Cattanach BM, et al. (1993) New mutations at the tabby locus. Mouse Genome 91(1):116 |
| abstractText | Full text of MNL contribution: Research News: 4. New mutations at the tabby locus. Five new Ta mutations have recently been recovered. Three (Ta29H, Ta30H and Ta32H) derived from radiation studies, Ta29H and Ta32H appearing following paternal X-irradiation (3 + 3 Gy, 24h fractionated dose applied to spermatogonia), and Ta30H detected following maternal 4 Gy X-irradiation. All three mutations appeared identical to the original TaFa mutation, showing the typical striped coat phenotype in heterozygotes and the characteristic coat type, naked tails with distal kink and tooth abnormalities in the hemizygotes. None showed the reduced viability and other anomalies that characterise Ta25H deletion (Cattanach et al, Cytogenet. and Cell Genet. 56:137-143, 1991). The other two mutations were of spontaneous origin. One (Ta26H) occurred as a gonosomic mutation in our hpg stock, while the other (Ta33H) appeared in a control group of a specific locus mutation experiment. Both of these mutations differed from the original TaFa mutation in that the hemizygotes exhibit a hairy tail, lacking kinks, possess a coarser coat still comprised exclusively of awls, and barely exhibit the characteristic bald patches behind the ears. The striped heterozygous phenotype was with each mutation somewhat less distinct than evident with TaFa. Consistent with the modified coat phenotype, vibrissa counts on 21 Ta33H females were near-normal (mean = 18.76 cf 19), in contrast to that for Ta23H + females, for example, which on a comparable genetic background have given a mean vibrissa score of 15.21 (Cattanach et a1 MNL 83: 160-161, 1989). Likewise, the mean score of 10 Ta33H Y males was 14.5, greatly exceeding that for Ta23H Y males (5.77), with some individuals having scores of 17 and 18. None of the Ta33H Y males observed so far have displayed the gross tooth abnormalities commonly found with TaFa Y males that necessitate the use of special feeding procedures (Cattanach and Rasberry). (This study was supported in part by Euratom contract Bi6- 143). |
