Primary Identifier | MGI:3619330 | Organism | mouse, laboratory |
Chromosome | 4 | NCBI Gene Number | 723895 |
Mgi Type | miRNA gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Acts upstream of or within several processes, including cellular response to decreased oxygen levels; cellular response to forskolin; and sensory perception of sound. Is expressed in several structures, including central nervous system; eye; genitourinary system; hemolymphoid system gland; and tooth. Human ortholog(s) of this gene implicated in colorectal cancer and nasopharynx carcinoma. Orthologous to human MIR31 (microRNA 31). PHENOTYPE: Mice homozygous for knock-out allele exhibit hypolactation and abnormalities in mammary gland development including a reduction of mammary stem cells, impaired cell proliferation, and precocious differentiation of the alveolar epithelium followed by subsequent defect in alveolar development. [provided by MGI curators] |