| First Author | Sun F | Year | 2009 |
| Journal | Biochem Biophys Res Commun | Volume | 380 |
| Issue | 3 | Pages | 660-5 |
| PubMed ID | 19285018 | Mgi Jnum | J:147061 |
| Mgi Id | MGI:3839181 | Doi | 10.1016/j.bbrc.2009.01.161 |
| Citation | Sun F, et al. (2009) Characterization of function and regulation of miR-24-1 and miR-31. Biochem Biophys Res Commun 380(3):660-5 |
| abstractText | To date, numerous microRNAs (miRNAs) have been discovered. However, the function of these miRNAs is largely unknown. While our knowledge of miRNA post-transcriptional processing has greatly expanded in recent years, we have a limited understanding of the regulation and transcription of miRNA genes. In this study, we characterized two BMP-2 upregulated miRNAs, miR-24-1 and miR-31, in mesenchymal stem cells and showed their opposing function in controlling cellular proliferation, and adipogenesis. Furthermore, we are the first to identify and characterize mouse intronic miR-23b~27b~24-1 and intergenic miR-31 genes. Moreover, we found that pri-miR-23b, pri-miR-27b, and pri-miR-24-1 are transcribed independently and their expression profiles are unique when cells are treated with BMP-2, even though they are located closely together. |
