| First Author | Yamagishi M | Year | 2012 |
| Journal | Cancer Cell | Volume | 21 |
| Issue | 1 | Pages | 121-35 |
| PubMed ID | 22264793 | Mgi Jnum | J:180277 |
| Mgi Id | MGI:5306052 | Doi | 10.1016/j.ccr.2011.12.015 |
| Citation | Yamagishi M, et al. (2012) Polycomb-Mediated Loss of miR-31 Activates NIK-Dependent NF-kappaB Pathway in Adult T Cell Leukemia and Other Cancers. Cancer Cell 21(1):121-35 |
| abstractText | Constitutive NF-kappaB activation has causative roles in adult T cell leukemia (ATL) caused by HTLV-1 and other cancers. Here, we report a pathway involving Polycomb-mediated miRNA silencing and NF-kappaB activation. We determine the miRNA signatures and reveal miR-31 loss in primary ATL cells. MiR-31 negatively regulates the noncanonical NF-kappaB pathway by targeting NF-kappaB inducing kinase (NIK). Loss of miR-31 therefore triggers oncogenic signaling. In ATL cells, miR-31 level is epigenetically regulated, and aberrant upregulation of Polycomb proteins contribute to miR-31 downregulation in an epigenetic fashion, leading to activation of NF-kappaB and apoptosis resistance. Furthermore, this emerging circuit operates in other cancers and receptor-initiated NF-kappaB cascade. Our findings provide a perspective involving the epigenetic program, inflammatory responses, and oncogenic signaling. |
