Primary Identifier | MGI:4838322 | Allele Type | Targeted |
Gene | Ttn | Transmission | Germline |
Strain of Origin | 129S2/SvPas | Is Recombinase | false |
Is Wild Type | false |
molecularNote | The sequence encoding a portion of the Mex 6 domain sequence GAA ATA ACA TGG was replaced by GTG AAA GAA AAA in order to lead to the modification of the four amino acids EITW to VKEK as occurs in the FINmaj mutation. In addition, a floxed neo cassette was inserted with the 3' region. The selection cassette was removed by Cre mediated recombination. |