| First Author | Cerella C | Year | 2015 |
| Journal | Cancer Lett | Volume | 356 |
| Issue | 2 Pt A | Pages | 251-62 |
| PubMed ID | 24530513 | Mgi Jnum | J:216637 |
| Mgi Id | MGI:5609121 | Doi | 10.1016/j.canlet.2014.02.008 |
| Citation | Cerella C, et al. (2015) Antagonistic role of natural compounds in mTOR-mediated metabolic reprogramming. Cancer Lett 356(2):251-62 |
| abstractText | Cells reprogram their metabolism very early during carcinogenesis; this event is critical for the establishment of other cancer hallmarks. Many oncogenes and tumor suppressor genes control metabolism by interplaying with the existing nutrient-sensing intracellular pathways. Mammalian target of rapamycin, mTOR, is emerging as a collector and sorter of a metabolic network controlling upstream and downstream modulation of these same genes. Natural compounds represent a source of anti-cancer molecules with chemopreventive and therapeutic properties. This review describes selected pathways and genes orchestrating the metabolic reprogramming and discusses the potential of natural compounds to target oncogenic metabolic aberrations. |
