| First Author | Xue B | Year | 2005 |
| Journal | FEBS Lett | Volume | 579 |
| Issue | 19 | Pages | 4081-7 |
| PubMed ID | 16023107 | Mgi Jnum | J:172998 |
| Mgi Id | MGI:5009411 | Doi | 10.1016/j.febslet.2005.06.034 |
| Citation | Xue B, et al. (2005) Regulation of lipopolysaccharide-induced inflammatory response by glutathione S-transferase P1 in RAW264.7 cells. FEBS Lett 579(19):4081-7 |
| abstractText | Glutathione S-transferase P1(GSTP1) plays an important role in the detoxification and xenobiotics metabolism. Here, we show that GSTP1 is also involved in LPS (lipopolysaccharide)-induced inflammatory response. GSTP1 expression, determined at the transcription and translation levels, were upregulated by the LPS stimulation in RAW264.7 macrophage-like cells. GSTP1 inhibited LPS-induced mitogen-activated protein kinases MAPKs including ERK, JNK and p38 as well as NF-kappaB activation dose- and time-dependently in transient transfected and stable transfected cells. Moreover this inhibition of the signaling pathways resulted in the decrease of tumor necrosis factor alpha (TNF-alpha) and nitric oxide (NO) synthesis. These data suggest that the GSTP1 prevents LPS-induced excessive production of pro-inflammatory factors and plays an anti-inflammatory role in response to LPS. |
