| First Author | Kozono T | Year | 2018 |
| Journal | J Biochem | Volume | 164 |
| Issue | 4 | Pages | 303-311 |
| PubMed ID | 29878215 | Mgi Jnum | J:287130 |
| Mgi Id | MGI:6415450 | Doi | 10.1093/jb/mvy053 |
| Citation | Kozono T, et al. (2018) Jaw1/LRMP has a role in maintaining nuclear shape via interaction with SUN proteins. J Biochem 164(4):303-311 |
| abstractText | Jaw1/LRMP is characterized as a Type II integral membrane protein that is localized to endoplasmic reticulum, however, its physiological functions have been poorly understood. An alignment of amino acid sequence of Jaw1 with Klarsicht/ANC-1/Syne/homology (KASH) proteins, outer nuclear membrane proteins, revealed that Jaw1 has a partial homology to the KASH domain. Here, we show that the function of Jaw1 is to maintain nuclear shape in mouse melanoma cell line. The siRNA-mediated knockdown of Jaw1 caused a severe defect in nuclear shape, and the defect was rescued by ectopic expression of siRNA-resistant Jaw1. Since co-immunoprecipitation assay indicates that Jaw1 interacts with Sad-1/UNC-84 (SUN) proteins that are inner nuclear proteins and microtubules, this study suggests that Jaw1 has a role in maintaining nuclear shape via interactions with SUN proteins and microtubules. |
