|  Help  |  About  |  Contact Us

Publication : SUN1 is required for telomere attachment to nuclear envelope and gametogenesis in mice.

First Author  Ding X Year  2007
Journal  Dev Cell Volume  12
Issue  6 Pages  863-72
PubMed ID  17543860 Mgi Jnum  J:122602
Mgi Id  MGI:3714869 Doi  10.1016/j.devcel.2007.03.018
Citation  Ding X, et al. (2007) SUN1 is required for telomere attachment to nuclear envelope and gametogenesis in mice. Dev Cell 12(6):863-72
abstractText  Prior to the pairing and recombination between homologous chromosomes during meiosis, telomeres attach to the nuclear envelope and form a transient cluster. However, the protein factors mediating meiotic telomere attachment to the nuclear envelope and the requirement of this attachment for homolog pairing and synapsis have not been determined in animals. Here we show that the inner nuclear membrane protein SUN1 specifically associates with telomeres between the leptotene and diplotene stages during meiotic prophase I. Disruption of Sun1 in mice prevents telomere attachment to the nuclear envelope, efficient homolog pairing, and synapsis formation in meiosis. Massive apoptotic events are induced in the mutant gonads, leading to the abolishment of both spermatogenesis and oogenesis. This study provides genetic evidence that SUN1-telomere interaction is essential for telomere dynamic movement and is required for efficient homologous chromosome pairing/synapsis during mammalian gametogenesis.
Quick Links:
 
Quick Links:
 

Expression

Publication --> Expression annotations

 

Other

6 Authors

9 Bio Entities

Trail: Publication

0 Expression