| First Author | Mirakaj V | Year | 2011 |
| Journal | J Immunol | Volume | 186 |
| Issue | 1 | Pages | 549-55 |
| PubMed ID | 21098235 | Mgi Jnum | J:168004 |
| Mgi Id | MGI:4881592 | Doi | 10.4049/jimmunol.1002671 |
| Citation | Mirakaj V, et al. (2011) Netrin-1 signaling dampens inflammatory peritonitis. J Immunol 186(1):549-55 |
| abstractText | Previous studies implicated the anti-inflammatory potential of the adenosine 2B receptor (A2BAR). A2BAR activation is achieved through adenosine, but this is limited by its very short t(1/2). To further define alternative adenosine signaling, we examined the role of netrin-1 during acute inflammatory peritonitis. In this article, we report that animals with endogenous repression of netrin-1 (Ntn1(+/-)) demonstrated increased cell count, increased peritoneal cytokine concentration, and pronounced histological changes compared with controls in a model of zymosan A peritonitis. Exogenous netrin-1 significantly decreased i.p. inflammatory changes. This effect was not present in animals with deletion of A2BAR (A2BAR(-/-)). A2BAR(-/-) animals demonstrated no change in cell count, i.p. cytokine concentration, or histology in response to netrin-1 injection. These data strengthen the role of netrin-1 as an immunomodulatory protein exerting its function in dependence of the A2BAR and further define alternative adenosine receptor signaling. |
