| First Author | Na YJ | Year | 2009 |
| Journal | Exp Mol Med | Volume | 41 |
| Issue | 9 | Pages | 638-47 |
| PubMed ID | 19478556 | Mgi Jnum | J:356460 |
| Mgi Id | MGI:7762552 | Doi | 10.3858/emm.2009.41.9.070 |
| Citation | Na YJ, et al. (2009) Comprehensive analysis of microRNA-mRNA co-expression in circadian rhythm. Exp Mol Med 41(9):638-47 |
| abstractText | To investigate the potential role of microRNA (miRNA) in the regulation of circadian rhythm, we performed microarray-based expression profiling study of both miRNA and mRNA in mouse liver for 48 h at 4-hour intervals. Circadian miRNA-mRNA target pair is defined as the pair both elements of which show circadian expression patterns and the sequence-based target relationship of which can be predicted. Circadian initiators, Clock and Bmal1, showed inversely correlated circadian expression patterns against their corresponding miRNAs, miR-181d and miR-191, targeting them. In contrast, circadian suppressors, Per, Cry, CKIe and Rev-erba, exhibited positively correlated circadian expression patterns to their corresponding miRNAs. Genomic location analysis revealed that intronic region showed higher abundance of cyclic than non-cyclic miRNAs targeting circadian genes while other (i.e., 3-UTR, exon and intergenic) regions showed no difference. It is suggested that miRNAs are involved in the regulation of peripheral circadian rhythm in mouse liver by modulating Clock:Bmal1 complex. Identifying specific miRNAs and their targets that are critically involved in circadian rhythm will provide a better understanding of the regulation of circadian- clock system. |
