| First Author | Sabbah A | Year | 2009 |
| Journal | Nat Immunol | Volume | 10 |
| Issue | 10 | Pages | 1073-80 |
| PubMed ID | 19701189 | Mgi Jnum | J:152795 |
| Mgi Id | MGI:4359985 | Doi | 10.1038/ni.1782 |
| Citation | Sabbah A, et al. (2009) Activation of innate immune antiviral responses by Nod2. Nat Immunol 10(10):1073-80 |
| abstractText | Pattern-recognition receptors (PRRs), including Toll-like receptors (TLRs) and RIG-like helicase (RLH) receptors, are involved in innate immune antiviral responses. Here we show that nucleotide-binding oligomerization domain 2 (Nod2) can also function as a cytoplasmic viral PRR by triggering activation of interferon-regulatory factor 3 (IRF3) and production of interferon-beta (IFN-beta). After recognition of a viral ssRNA genome, Nod2 used the adaptor protein MAVS to activate IRF3. Nod2-deficient mice failed to produce interferon efficiently and showed enhanced susceptibility to virus-induced pathogenesis. Thus, the function of Nod2 as a viral PRR highlights the important function of Nod2 in host antiviral defense mechanisms. |
