| First Author | Zhang J | Year | 2023 |
| Journal | Life Sci Alliance | Volume | 6 |
| Issue | 8 | PubMed ID | 37311583 |
| Mgi Jnum | J:352923 | Mgi Id | MGI:7491130 |
| Doi | 10.26508/lsa.202201869 | Citation | Zhang J, et al. (2023) An immune-based tool platform for in vivo cell clearance. Life Sci Alliance 6(8) |
| abstractText | Immunological targeting of pathological cells has been successful in oncology and is expanding to other pathobiological contexts. Here, we present a flexible platform that allows labeling cells of interest with the surface-expressed model antigen ovalbumin (OVA), which can be eliminated via either antigen-specific T cells or newly developed OVA antibodies. We demonstrate that hepatocytes can be effectively targeted by either modality. In contrast, pro-fibrotic fibroblasts associated with pulmonary fibrosis are only eliminated by T cells in initial experiments, which reduced collagen deposition in a fibrosis model. This new experimental platform will facilitate development of immune-based approaches to clear potential pathological cell types in vivo. |
