| Primary Identifier | MGI:2678106 | Allele Type | Targeted |
| Attribute String | Null/knockout | Gene | Plk2 |
| Transmission | Germline | Strain of Origin | 129S6/SvEvTac |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | A 750 bp fragment encompassing a portion of exon 1 and all of exon 2 was replaced with a neomycin selection cassette inserted by homologous recombination. Truncated transcript consisting of the neo cassette and portions of intron 2 and exon 3. The mutant transcript lacks sequence encoding the first 2 kinase domains which include the conserved putative ATP-binding pocket. Protein was undetected by Western blot analysis of homozygous mutant MEFs. |
