| First Author | Rajagopalan G | Year | 2007 |
| Journal | Autoimmunity | Volume | 40 |
| Issue | 3 | Pages | 169-79 |
| PubMed ID | 17453715 | Mgi Jnum | J:136978 |
| Mgi Id | MGI:3797453 | Doi | 10.1080/08916930701201083 |
| Citation | Rajagopalan G, et al. (2007) Autoimmunity in HLA-DQ8 transgenic mice expressing granulocyte/macrophage-colony stimulating factor in the beta cells of islets of Langerhans. Autoimmunity 40(3):169-79 |
| abstractText | Type 1 diabetes (T1D) is a polygenic autoimmune disease with a strong HLA association particularly, HLA-DQ8. We investigated whether islet-specific expression of granulocyte/macrophage colony-stimulating factor (Ins.GM-CSF) in A Beta degrees.NOD.DQ8 mice (HLA-DQ8 transgenic mice on a NOD background lacking endogenous mouse MHC class II molecules) would predispose to development of spontaneous autoimmune diabetes. A Beta degrees.NOD.DQ8 mice expressing GM-CSF in the pancreatic ss cells (8+ G+) as well as litter mates lacking either HLA-DQ8 (8 |
