| First Author | Iwai Y | Year | 2021 |
| Journal | Front Neural Circuits | Volume | 15 |
| Pages | 658343 | PubMed ID | 33828463 |
| Mgi Jnum | J:333806 | Mgi Id | MGI:7439752 |
| Doi | 10.3389/fncir.2021.658343 | Citation | Iwai Y, et al. (2021) Transient Astrocytic Gq Signaling Underlies Remote Memory Enhancement. Front Neural Circuits 15:658343 |
| abstractText | Astrocytes elicit transient Ca(2+) elevations induced by G protein-coupled receptors (GPCRs), yet their role in vivo remains unknown. To address this, transgenic mice with astrocytic expression of the optogenetic Gq-type GPCR, Optoalpha1AR, were established, in which transient Ca(2+) elevations similar to those in wild type mice were induced by brief blue light illumination. Activation of cortical astrocytes resulted in an adenosine A1 receptor-dependent inhibition of neuronal activity. Moreover, sensory stimulation with astrocytic activation induced long-term depression of sensory evoked response. At the behavioral level, repeated astrocytic activation in the anterior cortex gradually affected novel open field exploratory behavior, and remote memory was enhanced in a novel object recognition task. These effects were blocked by A1 receptor antagonism. Together, we demonstrate that GPCR-triggered Ca(2+) elevation in cortical astrocytes has causal impacts on neuronal activity and behavior. |
