| First Author | Zhu Y | Year | 2002 |
| Journal | Science | Volume | 295 |
| Issue | 5554 | Pages | 505-8 |
| PubMed ID | 11799247 | Mgi Jnum | J:73898 |
| Mgi Id | MGI:2157165 | Doi | 10.1126/science.1065250 |
| Citation | Zhu Y, et al. (2002) Abnormal vascular function and hypertension in mice deficient in estrogen receptor beta. Science 295(5554):505-8 |
| abstractText | Blood vessels express estrogen receptors, but their role in cardiovascular physiology is not well understood. We show that vascular smooth muscle cells and blood vessels from estrogen receptor beta (ERbeta)-deficient mice exhibit multiple functional abnormalities. In wild-type mouse blood vessels, estrogen attenuates vasoconstriction by an ERbeta-mediated increase in inducible nitric oxide synthase expression. In contrast, estrogen augments vasoconstriction in blood vessels from ERbeta-deficient mice. Vascular smooth muscle cells isolated from ERbeta-deficient mice show multiple abnormalities of ion channel function. Furthermore, ERbeta-deficient mice develop sustained systolic and diastolic hypertension as they age. These data support an essential role for ERbeta in the regulation of vascular function and blood pressure. |
