| First Author | Haaijman JJ | Year | 1977 |
| Journal | Immunology | Volume | 32 |
| Issue | 4 | Pages | 427-34 |
| PubMed ID | 608677 | Mgi Jnum | J:35659 |
| Mgi Id | MGI:83108 | Citation | Haaijman JJ, et al. (1977) Immunoglobulin-containing cells in different lymphoid organs of the CBA mouse during its life-span. Immunology 32(4):427-34 |
| abstractText | The number of cells containing cytoplasmic immunoglobulin (C-Ig cells) was determined in the spleen, mesenteric lymph nodes, bone marrow and Peyer's patches of CBA mice of different ages. A rapid increase in the number of C-Ig cells at between 2 and 6 weeks of age was observed in spleen and gut-associated lymphoid organs. The absolute number of C-Ig cells in these organs decreases with advancing age. In the bone marrow, the number of C-Ig cells increases steadily with age up to one year. From one year on, the number remains approximately constant in the males. In female mice, the number of C-Ig cells, mainly of the IgA class, increases sharply around 1 year of age. The spleen is the major site of Ig synthesis up to about 6 months of age. In older animals, the relative contribution of the bone marrow increases with age, possibly due to a gradual shift in the individual animal from primary type responses to a pattern of secondary type responses. No indication of a decreased overall immunological activity in senescence was obtained. |
