| First Author | Schäfer U | Year | 2000 |
| Journal | FEBS Lett | Volume | 466 |
| Issue | 1 | Pages | 148-54 |
| PubMed ID | 10648831 | Mgi Jnum | J:60167 |
| Mgi Id | MGI:1352932 | Doi | 10.1016/s0014-5793(99)01778-0 |
| Citation | Schafer U, et al. (2000) Isolation and characterisation of the human rab18 gene after stimulation of endothelial cells with histamine. FEBS Lett 466(1):148-54 |
| abstractText | Here we report the isolation of a cDNA encoding the complete human rab18 protein from histamine-stimulated endothelial cells using differential display. The amino acid sequence showed 98% homology with the previously isolated mouse rab18 protein, which is implicated in apical/basolateral endocytosis. Northern blot analysis revealed two transcripts (2.5 kb and 1 kb) ubiquitously expressed in all examined organs, as well as in human umbilical vein endothelial and aortic cells. In blood cells rab18 transcripts were hardly detectable. The histamine-induced time-dependent increase of rab18 mRNA expression in human umbilical vein endothelial cells and peripheral blood mononuclear cells indicates for the first time a link between receptor-mediated signal transduction and the regulation of rab gene expression. This finding might also imply a role for rab proteins in inflammation. |
