Primary Identifier | MGI:2451290 | Allele Type | Targeted |
Attribute String | Null/knockout | Gene | Atp1a1 |
Transmission | Germline | Strain of Origin | 129P2/OlaHsd |
Is Recombinase | false | Is Wild Type | false |
molecularNote | Exons 15 through 18 were replaced with an hprt cassette via homologous recombination. Both alpha 1 transcript and protein levels were reduced by ~40% in heterozygous mutant hearts. An aberrant alpha 1 transcript was detected but was not expected to produce a functional protein. |