Primary Identifier | MGI:2667725 | Organism | mouse, laboratory |
Chromosome | 12 | NCBI Gene Number | 217847 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.3.0) Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be involved in blood coagulation. Predicted to act upstream of or within hemostasis. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in dorsal root ganglion; liver lobe; pancreas; and urinary system. Human ortholog(s) of this gene implicated in thrombophilia. Orthologous to human SERPINA10 (serpin family A member 10). PHENOTYPE: Mice homozygous for a knock-out allele display a reduced survival rate, enhanced thrombosis after ferric chloride-induced carotid artery injury, and increased mortality from pulmonary thromboembolism following collagen/epinephrine infusion. [provided by MGI curators] |