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Publication : A global genomic transcriptional code associated with CNS-expressed genes.

First Author  Bailey PJ Year  2006
Journal  Exp Cell Res Volume  312
Issue  16 Pages  3108-19
PubMed ID  16919269 Mgi Jnum  J:112701
Mgi Id  MGI:3663207 Doi  10.1016/j.yexcr.2006.06.017
Citation  Bailey PJ, et al. (2006) A global genomic transcriptional code associated with CNS-expressed genes. Exp Cell Res 312(16):3108-19
abstractText  Highly conserved non-coding DNA regions (HCNR) occur frequently in vertebrate genomes, but their functional roles remain unclear. Here, we provide evidence that a large portion of HCNRs are enriched for binding sites for Sox, POU and Homeodomain transcription factors, and such HCNRs can act as cis-regulatory regions active in neural stem cells. Strikingly, these HCNRs are linked to several hundreds of genes expressed in the developing CNS and they may exert locus-wide regulatory effects on multiple genes flanking their genomic location. Moreover, these data imply a unifying transcriptional logic for a large set of CNS-expressed genes in which Sox and POU proteins act as generic promoters of transcription while Homeodomain proteins control the spatial expression of genes through active repression.
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