First Author | Bailey PJ | Year | 2006 |
Journal | Exp Cell Res | Volume | 312 |
Issue | 16 | Pages | 3108-19 |
PubMed ID | 16919269 | Mgi Jnum | J:112701 |
Mgi Id | MGI:3663207 | Doi | 10.1016/j.yexcr.2006.06.017 |
Citation | Bailey PJ, et al. (2006) A global genomic transcriptional code associated with CNS-expressed genes. Exp Cell Res 312(16):3108-19 |
abstractText | Highly conserved non-coding DNA regions (HCNR) occur frequently in vertebrate genomes, but their functional roles remain unclear. Here, we provide evidence that a large portion of HCNRs are enriched for binding sites for Sox, POU and Homeodomain transcription factors, and such HCNRs can act as cis-regulatory regions active in neural stem cells. Strikingly, these HCNRs are linked to several hundreds of genes expressed in the developing CNS and they may exert locus-wide regulatory effects on multiple genes flanking their genomic location. Moreover, these data imply a unifying transcriptional logic for a large set of CNS-expressed genes in which Sox and POU proteins act as generic promoters of transcription while Homeodomain proteins control the spatial expression of genes through active repression. |