| First Author | Nakamura M | Year | 2009 |
| Journal | Gene | Volume | 445 |
| Issue | 1-2 | Pages | 66-72 |
| PubMed ID | 19539733 | Mgi Jnum | J:151512 |
| Mgi Id | MGI:4353966 | Doi | 10.1016/j.gene.2009.06.003 |
| Citation | Nakamura M, et al. (2009) c-Maf is essential for the F4/80 expression in macrophages in vivo. Gene 445(1-2):66-72 |
| abstractText | c-Maf, which is one of the large Maf transcription factors, can bind to Maf recognition element (MARE) and activates transcription of target genes. Although c-Maf is expressed in macrophages and directly regulates the expression of interleukin-10, detailed information regarding its function in the null mutant phenotype of tissue macrophages remain unknown. In this study, we demonstrated that c-Maf is specifically expressed in the F4/80 positive fetal liver and adult macrophages. The expression of F4/80, which is a tissue macrophage-specific seven trans-membrane receptor, was dramatically suppressed in the c-Maf-deficient macrophage, whereas the expression of Mac-1 was not affected, suggesting that c-Maf is not necessary for the lineage commitment of macrophages. Luciferase reporter and EMSA showed that c-Maf directly regulates the expression of F4/80 by interacting with the half-MARE site of the F4/80 promoter. These results suggest that c-Maf is required for the F4/80 expression in macrophages in vivo. |
