| First Author | Sheih A | Year | 2017 |
| Journal | Mucosal Immunol | Volume | 10 |
| Issue | 3 | Pages | 705-715 |
| PubMed ID | 27731325 | Mgi Jnum | J:307711 |
| Mgi Id | MGI:6724426 | Doi | 10.1038/mi.2016.90 |
| Citation | Sheih A, et al. (2017) GM-CSF produced by the airway epithelium is required for sensitization to cockroach allergen. Mucosal Immunol 10(3):705-715 |
| abstractText | Airway epithelial cells are among the first to encounter inhaled allergens and can initiate allergic responses by producing pro-Th2 innate cytokines. In this study, we investigated the role of epithelial-derived cytokines in sensitization to a clinically relevant allergen, cockroach allergen (CRA). Among the epithelial-derived cytokines, granulocyte macrophage colony-stimulating factor (GM-CSF) had a central role in the initiation of Th2 allergic responses to CRA. We show that initial exposure to CRA directly activated airway epithelial cells through a TLR4-MyD88-dependent pathway and MyD88 signaling in epithelial cells induced upregulation of GM-CSF during sensitization. Epithelial-derived GM-CSF was required for allergic sensitization and selectively restored Th2 responses in the absence of MyD88. Thus, we demonstrate that epithelial-derived GM-CSF is a critical early signal during allergic sensitization to CRA. |
