| First Author | Hsu CY | Year | 2008 |
| Journal | Biochem Biophys Res Commun | Volume | 376 |
| Issue | 3 | Pages | 466-71 |
| PubMed ID | 18801334 | Mgi Jnum | J:141306 |
| Mgi Id | MGI:3818102 | Doi | 10.1016/j.bbrc.2008.08.170 |
| Citation | Hsu CY, et al. (2008) LUZP deficiency affects neural tube closure during brain development. Biochem Biophys Res Commun 376(3):466-71 |
| abstractText | LUZP is a leucine zipper-containing protein predominantly expressed in the brain. The functional significance of LUZP remains unknown. To explore the role of LUZP in brain development, a knockout mouse strain with a lacZ knock-in (Luzp-KO/lacZ-KI) has been established. LacZ reporter expression driven by the endogenous Luzp promoter was detected in the neuroepithelium and the cardiac tissue. Luzp(-/-) mice exhibited perinatal death, presumably due to the accompanied complex cardiovascular defects. Luzp(-/-) embryos displayed a cranial neural tube closure defect (NTD), with exposed brain tissues. Ectopic expression of Sonic-hedgehog, which is a protein known to be involved in neural tube closure, and elevated apoptosis were observed in the dorsal lateral neuroepithelium of the NTD Luzp(-/-) hindbrain. These findings assign a novel function of LUZP in the embryonic development of brain. |
