| Primary Identifier | MGI:109249 | Organism | mouse, laboratory |
| Chromosome | 16 | NCBI Gene Number | 11504 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.4.0) Enables heparin binding activity and metalloendopeptidase activity. Acts upstream of or within heart trabecula formation; kidney development; and ovulation from ovarian follicle. Located in basement membrane and cytoplasmic vesicle. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; genitourinary system; and sensory organ. Used to study urinary tract obstruction. Orthologous to human ADAMTS1 (ADAM metallopeptidase with thrombospondin type 1 motif 1). PHENOTYPE: Mice homozygous for targeted mutations that inactivate the gene display growth retardation with adipose tissue malformation, impaired female fertility, enlarged renal calices and abnormal adrenal medullary architecture. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
