| First Author | Yockey LJ | Year | 2013 |
| Journal | J Invest Dermatol | Volume | 133 |
| Issue | 12 | Pages | 2714-2721 |
| PubMed ID | 23698100 | Mgi Jnum | J:202873 |
| Mgi Id | MGI:5522635 | Doi | 10.1038/jid.2013.228 |
| Citation | Yockey LJ, et al. (2013) The Absence of a Microbiota Enhances TSLP Expression in Mice with Defective Skin Barrier but Does Not Affect the Severity of their Allergic Inflammation. J Invest Dermatol 133(12):2714-21 |
| abstractText | Evidence is accumulating to suggest that our indigenous microbial communities (microbiota) may have a role in modulating allergic and immune disorders of the skin. To examine the link between the microbiota and atopic dermatitis (AD), we examined a mouse model of defective cutaneous barrier function with an AD-like disease due to loss of Notch signaling. Comparisons of conventionally raised and germ-free (GF) mice revealed a similar degree of allergic skin inflammation, systemic atopy, and airway hypersensitivity. GF mutant animals expressed significantly higher levels of thymic stromal lymphopoietin, a major proinflammatory cytokine released by skin with defective barrier function, resulting in a more severe B-lymphoproliferative disorder that persisted into adulthood. These findings suggest a role for the microbiota in ameliorating stress signals released by keratinocytes in response to perturbation in cutaneous barrier function. |
