| First Author | Fang W | Year | 1998 |
| Journal | Immunity | Volume | 9 |
| Issue | 1 | Pages | 35-45 |
| PubMed ID | 9697834 | Mgi Jnum | J:48864 |
| Mgi Id | MGI:1275897 | Doi | 10.1016/s1074-7613(00)80586-5 |
| Citation | Fang W, et al. (1998) Self-reactive B lymphocytes overexpressing Bcl-xL escape negative selection and are tolerized by clonal anergy and receptor editing. Immunity 9(1):35-45 |
| abstractText | Self-reactive B cells Tg for both a bcl-xL death inhibitory gene and an Ig receptor recognizing hen egg lysozyme (HEL-Ig) efficiently escaped developmental arrest and deletion in mice expressing membrane-bound self-antigen (mHEL). In response to the same antigen, Tg HEL-Ig B cells not expressing bcl-xL were deleted, while cells expressing bcl-2 were arrested at the immature B stage. Bcl-xL Tg B cells escaping negative selection were anergic in both in vitro and in vivo assays and showed some evidence for receptor editing. These studies suggest that Bcl-x may have a distinct role in controlling survival at the immature stage of B cell development and demonstrate that tolerance is preserved when self-reactive B cells escape central deletion. |
