| First Author | Ishibashi M | Year | 1995 |
| Journal | Genes Dev | Volume | 9 |
| Issue | 24 | Pages | 3136-48 |
| PubMed ID | 8543157 | Mgi Jnum | J:30431 |
| Mgi Id | MGI:77942 | Doi | 10.1101/gad.9.24.3136 |
| Citation | Ishibashi M, et al. (1995) Targeted disruption of mammalian hairy and Enhancer of split homolog-1 (HES-1) leads to up-regulation of neural helix-loop-helix factors, premature neurogenesis, and severe neural tube defects. Genes Dev 9(24):3136-48 |
| abstractText | Mammalian hairy and Enhancer of split homolog-1 (HES-1) encodes a helix-loop-helix (HLH) factor that is thought to act as a negative regulator of neurogenesis. To directly investigate the functions of HES-1 in mammalian embryogenesis, we performed a targeted disruption of the HES-1 locus. Mice homozygous for the mutation exhibited severe neurulation defects and died during gestation or just after birth. In the developing brain of HES-1-null embryos, expression of the neural differentiation factor Mash-1 and other neural HLH factors was up-regulated and postmitotic neurons appeared prematurely. These results suggest that HES-1 normally controls the proper timing of neurogenesis and regulates neural tube morphogenesis. |
