| First Author | Forni PE | Year | 2011 |
| Journal | J Neurosci | Volume | 31 |
| Issue | 18 | Pages | 6915-27 |
| PubMed ID | 21543621 | Mgi Jnum | J:171903 |
| Mgi Id | MGI:5002385 | Doi | 10.1523/JNEUROSCI.6087-10.2011 |
| Citation | Forni PE, et al. (2011) Neural Crest and Ectodermal Cells Intermix in the Nasal Placode to Give Rise to GnRH-1 Neurons, Sensory Neurons, and Olfactory Ensheathing Cells. J Neurosci 31(18):6915-27 |
| abstractText | The origin of GnRH-1 cells and olfactory ensheathing cells has been controversial. Genetic Cre-lox lineage tracing of the neural crest (NC) versus ectodermal contribution to the developing nasal placode was performed using two complementary mouse models, the NC-specific Wnt1Cre mouse line and an ectodermal-specific Crect mouse line. Using these lines we prove that the NC give rise to the olfactory ensheathing cells and subpopulations of GnRH-1 neurons, olfactory and vomeronasal cells. These data demonstrate that Schwann cells and olfactory ensheathing cells share a common developmental origin. Furthermore, the results indicate that certain conditions that impact olfaction and sexual development, such as Kallmann syndrome, may be in part neurocristopathies. |
