| First Author | Weil MM | Year | 1997 |
| Journal | Genomics | Volume | 45 |
| Issue | 3 | Pages | 626-8 |
| PubMed ID | 9367689 | Mgi Jnum | J:44257 |
| Mgi Id | MGI:1099632 | Doi | 10.1006/geno.1997.4999 |
| Citation | Weil MM, et al. (1997) Identification of quantitative trait loci controlling levels of radiation-induced thymocyte apoptosis in mice. Genomics 45(3):626-8 |
| abstractText | Thymocyte apoptosis levels are higher in C57BL/6J mice than in C3Hf/Kam mice. Low-dose irradiation increases the numbers of thymocytes undergoing apoptosis, but the strain difference persists. We mapped three loci controlling radiation-induced thymocyte apoptosis levels in F2 intercross progeny of these strains. The strongest association of a genomic region with an apoptosis level occurred in a region of chromosome 11 known to harbor a locus (or loci) important in the pathogenesis of several rodent models of autoimmune disease. Additional loci influencing radiation-induced thymocyte apoptosis were identified on chromosomes 9 and 16. The genetic polymorphisms underlying these loci may have an evolutionary role in fine-tuning the apoptotic response in T cells and may be important in the etiology of lymphoproliferative disorders and autoimmunity. |
