Primary Identifier | MGI:99632 | Organism | mouse, laboratory |
Chromosome | 1 | NCBI Gene Number | 98741 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Predicted to enable delayed rectifier potassium channel activity; protein heterodimerization activity; and transmembrane transporter binding activity. Predicted to be involved in action potential; potassium ion transmembrane transport; and protein localization to plasma membrane. Predicted to act upstream of or within monoatomic ion transmembrane transport. Predicted to be located in neuronal cell body membrane. Predicted to be part of voltage-gated potassium channel complex. Predicted to be active in dendrite; membrane; and neuronal cell body. Is expressed in several structures, including central nervous system; genitourinary system; hemolymphoid system gland; liver; and sensory organ. Orthologous to human KCNB2 (potassium voltage-gated channel subfamily B member 2). PHENOTYPE: Mice homozygous for a targeted mutation exhibit neurological abnormalities when compared with controls, including an abnormal sleep/wake cycle, decreased exploratory and locomotor activity, and a motor strength deficit. [provided by MGI curators] |