Primary Identifier | MGI:6197069 | Gene | Il4i1 |
Inheritance Mode | Semidominant | Strain of Origin | 129/Sv |
Is Recombinase | false | Is Wild Type | false |
molecularNote | This minor histocompatibility antigen, initially identified as being between C57BL/10ScSn and 129/Rr but also found to be between C57BL/6J and 129P3/J, is caused by a single amino acid change at residue 25, which is alanine in C57BL/6J-derived H46-a and methionine for 129-derived H46-b. The 2 nucleotide sequence variations underlying this are G73A and C74T and the core antigenic peptide from each compete similarly for binding Ab. The core antigenic peptide in H46-b is HMFVEAIPELQ. |