| First Author | Takeuchi T | Year | 2009 |
| Journal | Genes Cells | Volume | 14 |
| Issue | 8 | Pages | 941-7 |
| PubMed ID | 19624757 | Mgi Jnum | J:158257 |
| Mgi Id | MGI:4438331 | Doi | 10.1111/j.1365-2443.2009.01321.x |
| Citation | Takeuchi T, et al. (2009) Neither MafA/L-Maf nor MafB is essential for lens development in mice. Genes Cells 14(8):941-7 |
| abstractText | The importance of the large Maf transcription factor family has been investigated in lens development in the chick, Xenopus and mammals. Previously we reported that c-maf-deficient mice exhibit severe defects in lens fibre cells. Here, we report the roles of other large Mafs, MafA/L-Maf and MafB, during mouse lens development. MafA/L-Maf and MafB were expressed in lens epithelial cells and fibre cells at E12.5 but had largely disappeared from the lens at E18.5. The lens of mafA-, mafB-deficient and mafA::mafB double-deficient mice developed normally. In c-maf-deficient mice, the pattern of expression of MafA and MafB differed from their expression in wild-type mice. Moreover, the expression of crystallin genes was unchanged in mafA-, mafB- and mafA::mafB double-deficient lens. These results indicate that c-Maf alone is essential for lens development, and that MafA/L-Maf and MafB are dispensable in mice. |
